December is the month of Chlorthalidone

In December 4th, 2023, JAMA published a secondary analysis of outcomes of the famous Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) study. The objective was to determine the long-term posttrial risk of primary and secondary outcomes among trial participants who were randomized to either a thiazide-type diuretic, calcium channel blocker (CCB), or …

Tumor Lysis syndrome, in a nut shell

Either spontaneously or post treatment. Risk factors: Older age, CKD, high tumor burden, use of nephrotoxic drugs Clinical: AKI, convulsions, arrythmia, sudden cardiac death (-3: +7 days of treatment) Labs: Urea, creatinine, uric acid, K, Calcium, phosphorus, LDH Definition: 2 or more electrolytes disturbance Prevention: Hydration with IV fluids, aim 100 ml/hour, monitor for volume …